Article
The amino terminus of ADP-ribosylation factor (ARF) 1 is essential for interaction with Gs and ARF GTPase-activating protein.
The Journal of biological chemistry - 25 Nov 1994
Randazzo P A, Terui T, Sturch S, Kahn R A
Abstract excerpt
The role of the amino terminus in the actions of ADP-ribosylation factor 1 (ARF1) was examined by comparing wild type ARF1, a 13-residue NH2-terminal deletion mutant ([delta 13]ARF1), and a 17-residue NH2-terminal deletion mutant ([delta 17]ARF1). The amino-terminal 13 residues of ARF1 are required for cofactor activity in the ADP-ribosylation by cholera toxin when Gs is the substrate. This is in marked contrast...
Topics
- ADP-Ribosylation Factor 1
- ADP-Ribosylation Factors
- Animals
- Cattle
- GTP-Binding Proteins
- GTPase-Activating Proteins
- Mutation
- Proteins
- Sequence Deletion