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Article

Optimizing the nucleotide sequence of a meiotic recombination hotspot in Schizosaccharomyces pombe.

Genetics - 1 Apr 2005

Steiner Walter W, Smith Gerald R

Abstract excerpt

The ade6-M26 mutation of Schizosaccharomyces pombe created a meiotic recombination hotspot. Previous analyses indicated that the heptamer 5'-ATGACGT-3' was necessary and sufficient for hotspot activity; the Atf1-Pcr1 transcription factor binds to this sequence and activates M26. After finding cases in which the M26 heptamer in ade6 was, surprisingly, not active as a hotspot, we used an in vitro selection method...

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Source

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Identifiers

PMID: 15716492
DOI: 10.1534/genetics.104.039230
PMCID: PMC1449614

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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