Article
Susceptibility to autoimmune thyroiditis in Down's syndrome is associated with the major histocompatibility class II DQA 0301 allele.
Clinical endocrinology - 1 Sept 1994
Nicholson L B, Wong F S, Ewins D L, Butler J, Holland A, Demaine A G, McGregor A M
Abstract excerpt
OBJECTIVE: Abnormalities of immune function, including thyroid autoimmunity, are common features of Down's syndrome, and the genetic associations of autoimmune thyroiditis have been extensively studied in otherwise normal patients with thyroid disease. In this study we have examined the HLA assoc...
Topics
- Alleles
- Cohort Studies
- Disease Susceptibility
- Down Syndrome
- Female
- Genotype
- HLA-DQ Antigens
- HLA-DQ alpha-Chains
- Humans
- Male
- Middle Aged
- Polymorphism, Restriction Fragment Length
- Thyroiditis, Autoimmune