Alpha 1-antitrypsin Siiyama (Ser53-->Phe). Further evidence for intracellular loop-sheet polymerization.

Article

Alpha 1-antitrypsin Siiyama (Ser53-->Phe). Further evidence for intracellular loop-sheet polymerization.

The Journal of biological chemistry - 25 Jul 1993

Lomas D A, Finch J T, Seyama K, Nukiwa T, Carrell R W

Abstract excerpt

Antitrypsin Siiyama is a rare example of the deficiency variants of antitrypsin that accumulate in the endoplasmic reticulum of the hepatocyte. The common example is Z antitrypsin, which has a mutation (Glu342-->Lys) at the junction of the head of the fifth strand of the A sheet and the base of t...

Topics

Adult
Animals
Cattle
Chymotrypsin
Homozygote
Humans
Liver Diseases
Male
Microscopy, Electron
Models, Molecular
Mutation
Phenylalanine
Polymers
Serine
alpha 1-Antitrypsin

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