Article
Pipecolic acid is an osmoprotectant for Escherichia coli taken up by the general osmoporters ProU and ProP.
Microbiology (Reading, England) - 1 Sept 1994
Gouesbet G, Jebbar M, Talibart R, Bernard T, Blanco C
Abstract excerpt
Exogenously supplied L-pipecolic acid was accumulated by Escherichia coli cells and protected them while growing at inhibitory osmolarity. Using specific uptake mutants and competitive assays, we established that the imino acid enters the cells through the ProP and ProU systems with Km values of...
Topics
- Amino Acid Transport Systems
- Bacterial Proteins
- Betaine
- Binding, Competitive
- Biological Transport, Active
- Carrier Proteins
- Escherichia coli
- Escherichia coli Proteins
- Mutation
- Pipecolic Acids
- Symporters
- Water-Electrolyte Balance