Article
Hyper-IgM immunodeficiency with disseminated cryptococcosis.
Acta paediatrica (Oslo, Norway : 1992) - 1 Jul 1994
Iseki M, Anzo M, Yamashita N, Matsuo N
Abstract excerpt
We describe two siblings with X-linked hyper-IgM immunodeficiency. One patient developed disseminated cryptococcosis. Co-culture of this patient's T cells with normal B cells suppressed IgG and IgA production. The CD40 ligand gene of one patient was examined and contained a nonsense mutation at n...
Topics
- Antigens, CD
- CD40 Ligand
- Causality
- Child, Preschool
- Cryptococcosis
- Fatal Outcome
- Genetic Linkage
- Humans
- Hypergammaglobulinemia
- Immunoglobulin A
- Immunoglobulin G
- Immunoglobulin M
- Immunologic Deficiency Syndromes
- Infant
- Ligands
- Male
- Membrane Glycoproteins
- Mutation