Article
Formation of functional cross-species heterodimers of ornithine decarboxylase.
Biochemistry - 22 Nov 1994
Osterman A, Grishin N V, Kinch L N, Phillips M A
Abstract excerpt
The two active sites in ornithine decarboxylase (ODC) are formed at the dimer interface with Lys-69 and Cys-360 contributing to each active site from opposite monomers [Tobias, K. E., & Kahana, C. (1993) Biochemistry 32, 5842-5847]. To gain insight into the organization of the substrate binding s...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Binding Sites
- Escherichia coli
- Kinetics
- Leishmania donovani
- Mice
- Molecular Sequence Data
- Mutation
- Oligodeoxyribonucleotides
- Ornithine Decarboxylase
- Ornithine Decarboxylase Inhibitors
- Recombinant Proteins
- Species Specificity
- Substrate Specificity
- Trypanosoma brucei brucei