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Article

Formation of catalytically active cross-species heterodimers of thymidylate synthase from Plasmodium falciparum and Plasmodium vivax.

Molecular biology reports - 1 Feb 2011

Chanama Manee, Chanama Suchart, Shaw Philip J, Chitnumsub Penchit, Leartsakulpanich Ubolsree, Yuthavong Yongyuth

Abstract excerpt

Thymidylate synthase (TS) of Plasmodium dihydrofolate reductase-thymidylate synthase (DHFR-TS) functions as a homodimeric enzyme with two active sites located near the subunit interface. The dimerization is essential for catalysis, since the active site of each subunit contains amino acid residue...

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Source

Identifiers

PMID: 20577818
DOI: 10.1007/s11033-010-0199-7

Genes

DHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20577818-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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