Article
The effect of 5-fluorouracil and alpha interferon and 5-fluorouracil and leucovorin on cellular anti-tumour immune responses in patients with advanced colorectal cancer.
British journal of cancer - 1 Nov 1994
Nichols P H, Ward U, Ramsden C W, Primrose J N
Abstract excerpt
Interferon alpha (IFN-alpha) enhances the activity of 5-fluorouracil (5-FU) in the treatment of advanced colorectal cancer although the mechanism is not understood. We have investigated the effect of this combination on cellular immunity and compared this with standard therapy of 5-FU/L-leucovori...
Topics
- Adult
- Aged
- Antineoplastic Combined Chemotherapy Protocols
- Colorectal Neoplasms
- Drug Administration Schedule
- Female
- Fluorouracil
- Humans
- Immunity, Cellular
- Interferon alpha-2
- Interferon-alpha
- Killer Cells, Lymphokine-Activated
- Killer Cells, Natural
- Leucovorin