Article
Presynaptic dysfunction in Drosophila csp mutants.
Neuron - 1 Oct 1994
Umbach J A, Zinsmaier K E, Eberle K K, Buchner E, Benzer S, Gundersen C B
Abstract excerpt
Cysteine string proteins are synapse-specific proteins. In Drosophila, csp deletion mutants exhibit temperature-sensitive paralysis and early death. Here, we report that neuromuscular transmission is impaired presynaptically in these csp mutant larvae. At 22 degrees C, evoked transmitter release...
Topics
- Animals
- Calcium
- Drosophila
- Evoked Potentials
- Gene Deletion
- HSP40 Heat-Shock Proteins
- Larva
- Membrane Proteins
- Mutation
- Nerve Tissue Proteins
- Neuromuscular Junction
- Synapses
- Synaptic Membranes
- Synaptic Transmission
- Temperature