Article
Presynaptic dysfunction in Drosophila csp mutants.
Neuron - 1 Oct 1994
Umbach J A, Zinsmaier K E, Eberle K K, Buchner E, Benzer S, Gundersen C B
Abstract excerpt
Cysteine string proteins are synapse-specific proteins. In Drosophila, csp deletion mutants exhibit temperature-sensitive paralysis and early death. Here, we report that neuromuscular transmission is impaired presynaptically in these csp mutant larvae. At 22 degrees C, evoked transmitter release is depressed relative to wild type and rescued controls, and high frequency stimulation of the nerve leads to sporadic...
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