Article
Butyrate and acetyl-carnitine inhibit the cytogenetic expression of the fragile X in vitro.
American journal of medical genetics - 15 Jul 1994
Pomponi M G, Neri G
Abstract excerpt
Cytogenetic expression of the fragile site at Xq27.3 is only found in those patients who have a full mutation of the FMR1 gene, i.e., a large amplification of the CGG repeat. However, an expansion of this repeat, although necessary, does not seem to be sufficient to cause expression of fra(X)(q27...
Topics
- Acetylation
- Acetylcarnitine
- Adolescent
- Adult
- Aged
- Butyrates
- Butyric Acid
- Cells, Cultured
- Child
- Child, Preschool
- Chromosome Fragile Sites
- Chromosome Fragility
- Fragile X Syndrome
- Gene Expression
- Histones
- Humans
- Lymphocytes
- Male