Fragile X "gray zone" alleles: AGG patterns, expansion risks, and associated haplotypes.

doi:10.1002/(SICI)1096-8628(19960809)64:2<261::AID-AJMG5>3.0.CO;2-X

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Article

Fragile X "gray zone" alleles: AGG patterns, expansion risks, and associated haplotypes.

American journal of medical genetics - 9 Aug 1996

Zhong N, Ju W, Pietrofesa J, Wang D, Dobkin C, Brown W T

Abstract excerpt

The risk for fragile X "gray-zone" alleles to expand appears to depend on the absence of stabilizing AGGs, which interrupt the CGG repeat region. To characterize such alleles better, we analyzed a series of 101 chromosomes with triplet repeat lengths ranging from 35 to 59 for variations in their...

Topics

Alleles
Fragile X Syndrome
Genetic Markers
Genetic Variation
Haplotypes
Humans
Male
Risk Assessment
Risk Factors
Trinucleotide Repeats

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