Sex-specific processing of the Drosophila exuperantia transcript is regulated in male germ cells by the tra-2 gene.

doi:10.1073/pnas.91.22.10752

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Article

Sex-specific processing of the Drosophila exuperantia transcript is regulated in male germ cells by the tra-2 gene.

Proceedings of the National Academy of Sciences of the United States of America - 25 Oct 1994

Hazelrigg T, Tu C

Abstract excerpt

The Drosophila exuperantia (exu) gene encodes overlapping sex-specific, germline-dependent mRNAs. In this work, the structural differences between these sex-specific exu mRNAs were determined by sequence analysis of 9 ovary and 10 testis cDNAs. The transformer 2 (tra-2) gene functions in sex determination of female somatic cells through its role in regulating female-specific splicing of doublesex (dsx) RNA. We...

Topics

Alleles
Animals
Drosophila Proteins
Drosophila melanogaster
Egg Proteins
Female
Gene Expression Regulation
Gene Library
Homozygote
Male
Ovary

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

RNA, Messenger

RNA-Binding Proteins

Ribonucleoproteins

Sex Characteristics

Spermatozoa

Testis

Source

Open in PubMed Open full text

Identifiers

PMID: 7938024
DOI: 10.1073/pnas.91.22.10752
PMCID: PMC45100

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7938024-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Sex-specific processing of the Drosophila exuperantia transcript is regulated in male germ cells by the tra-2 gene.PMID 7938024Read ↗

Alternatively spliced transcripts of the sex-determining gene tra-2 of Drosophila encode functional proteins of different size.Semantic proximity Read ↗

A male-specific 3'-UTR regulates the steady-state level of the exuperantia mRNA during spermatogenesis in Drosophila.Semantic proximity Read ↗

Autoregulation of the splicing of transcripts from the transformer-2 gene of Drosophila.Semantic proximity Read ↗

The exuperantia gene is required for Drosophila spermatogenesis as well as anteroposterior polarity of the developing oocyte, and encodes overlapping sex-specific transcripts.Semantic proximity Read ↗

Regulation of sex-specific RNA splicing at the Drosophila doublesex gene: cis-acting mutations in exon sequences alter sex-specific RNA splicing patterns.Semantic proximity Read ↗

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Interspecific comparison of the transformer gene of Drosophila reveals an unusually high degree of evolutionary divergence.Semantic proximity Read ↗

Sxl-Dependent, tra/tra2-Independent Alternative Splicing of the Drosophila melanogaster X-Linked Gene found in neurons.Semantic proximity Read ↗

The human doublesex-related gene, DMRT2, is homologous to a gene involved in somitogenesis and encodes a potential bicistronic transcript.Semantic proximity Read ↗

roX1 RNA paints the X chromosome of male Drosophila and is regulated by the dosage compensation system.Semantic proximity Read ↗

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