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Article

Targeted mutagenesis of the phospholipase D gene results in decreased virulence of Corynebacterium pseudotuberculosis.

Molecular microbiology - 1 Jun 1994

McNamara P J, Bradley G A, Songer J G

Abstract excerpt

The chromosomal gene encoding the phospholipase D from Corynebacterium pseudotuberculosis (biovar ovis) isolate Whetten 1 was replaced with an allele containing a nonsense mutation. The virulence of the mutant strain (W1.31r1) and the isogenic parental strain were then compared by inoculation of goats. The wild-type strain caused abscessation at the site of infection, which then spread to the regional lymph node,...

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PMID: 7934899
DOI: 10.1111/j.1365-2958.1994.tb01080.x

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