Article
Development of papillary renal cell tumours is associated with loss of Y-chromosome-specific DNA sequences.
The Journal of pathology - 1 May 1994
Kovacs G, Tory K, Kovacs A
Abstract excerpt
Twenty-two papillary renal cell tumours were analysed by Southern hybridization using eight DNA probes from homologous regions of the X and Y chromosomes and two Y-chromosome-specific DNA probes. Sixteen of the 19 papillary renal cell tumours of male patients showed the loss of Y-chromosome-specific sequences. No loss of heterozygosity was detected in three tumours that developed in females. The frequency of loss...
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