Influence of genetic factors (HLA class II genes, insulin-gene region polymorphisms) and metabolic control on the development of diabetic nephropathy.

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Article

Influence of genetic factors (HLA class II genes, insulin-gene region polymorphisms) and metabolic control on the development of diabetic nephropathy.

Diabetes research (Edinburgh, Scotland) - 1 Jan 1993

Rønningen K S, Bangstad H J, Undlien D E, Thorsby E

Abstract excerpt

Both metabolic and genetic factors may contribute to the etiology of diabetic nephropathy. We selected 2 different groups of Type I diabetic patients in an attempt to evaluate both factors. HbA1c values and urinary albumin excretion were examined in 114 selected Type I diabetes patients with disease duration of more than 15 yr. We found signs of late renal complications in 28% of these patients. A clear...

Topics

Adult
Aged
Albuminuria
Alleles
Base Sequence
DNA Primers
Diabetes Mellitus, Type 1
Diabetic Nephropathies
Female
Genes, MHC Class II
HLA-DQ Antigens

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

HLA-DQ beta-Chains

HLA-DR Antigens

HLA-DRB1 Chains

Histocompatibility Antigens Class II

Humans

Insulin

Male

Source

Open in PubMed

Identifiers

PMID: 7924146

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7924146-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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