Transglutaminase facilitates the formation of polymers of the beta-amyloid peptide.

doi:10.1016/0006-8993(94)90688-2

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Article

Transglutaminase facilitates the formation of polymers of the beta-amyloid peptide.

Brain research - 18 Jul 1994

Dudek S M, Johnson G V

Abstract excerpt

One of the major pathological characteristics of Alzheimer's disease is the increased number of amyloid-containing senile plaques within the brain. The dense cores of these plaques are composed primarily of highly insoluble aggregates of a 39-43-residue peptide referred to as the beta-amyloid pep...

Topics

Alzheimer Disease
Amyloid beta-Peptides
Amyloidosis
Glycine
Humans
Lysine
Mutation
Transglutaminases

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