Adaptive evolution of highly mutable loci in pathogenic bacteria.

doi:10.1016/s0960-9822(00)00005-1

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Article

Adaptive evolution of highly mutable loci in pathogenic bacteria.

Current biology : CB - 1 Jan 1994

Moxon E R, Rainey P B, Nowak M A, Lenski R E

Abstract excerpt

Bacteria have specific loci that are highly mutable. We argue that the coexistence within bacterial genomes of such 'contingency' genes with high mutation rates, and 'housekeeping' genes with low mutation rates, is the result of adaptive evolution, and facilitates the efficient exploration of phe...

Topics

Animals
Bacteria
Base Sequence
Biological Evolution
DNA, Bacterial
Gene Conversion
Genes, Bacterial
Haemophilus influenzae
Humans
Models, Genetic
Molecular Sequence Data
Mutation
Phenotype
Recombination, Genetic
Repetitive Sequences, Nucleic Acid

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