Experimental evolution of evolvability

Abstract excerpt

Capacity to generate adaptive variation can evolve by natural selection. However, the idea that mutation becomes biased toward specific adaptive outcomes is controversial. Here, using experimental bacterial populations, we report the evolution of enhanced evolvability via localised hyper-mutation. Key to realisation was a lineage-level birth-death dynamic, where lineage success depended upon capacity to mutate bet...

Topics

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• Models, Genetic
• Mutation
• Adaptation, Biological
• Biological Evolution
• Escherichia coli
• Evolution, Molecular
• Phenotype
• Selection, Genetic

Identifiers and source

Literature Corpus work

e901bab2-cb15-5a19-91a6-b4d831b5b391

DOI

10.1101/2024.05.01.592015