On mixtures of three normal populations caused by monogenic inheritance: application to desipramine metabolism.

Article

On mixtures of three normal populations caused by monogenic inheritance: application to desipramine metabolism.

Journal of psychiatry & neuroscience : JPN - 1 Jul 1994

Miescke K J, Musa M N

Abstract excerpt

For a mixture of three normal distributions, which represent genotypes AA, Aa and aa, a method of estimation of the seven unknown parameters is proposed which works well whenever the phenotype (aa) is sufficiently well separated from the phenotype (AA, Aa). It is based on p-values of Kolmogorov's...

Topics

Adolescent
Adult
Algorithms
Depressive Disorder
Desipramine
Female
Genotype
Humans
Hydroxylation
Male
Middle Aged
Models, Genetic
Phenotype
Statistics, Nonparametric

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