Article
Protein aggregation and inclusion body formation in Escherichia coli rpoH mutant defective in heat shock protein induction.
FEBS letters - 21 Oct 1991
Gragerov A I, Martin E S, Krupenko M A, Kashlev M V, Nikiforov V G
Abstract excerpt
Mutations in the rpoH gene, encoding sigma 32, an alternative factor required for transcription of the heat shock genes, result in the extensive aggregation of virtually all cellular proteins and formation of inclusion bodies both under stress and non-stress conditions. Inhibitors of protein synthesis suppress this aggregation, suggesting that newly synthesized proteins preferentially aggregate in rpoH mutants....
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