Article
Deletions in the ligand for CD40 in X-linked immunoglobulin deficiency with normal or elevated IgM (HIGMX-1).
International immunology - 1 Jul 1993
Ramesh N, Fuleihan R, Ramesh V, Lederman S, Yellin M J, Sharma S, Chess L, Rosen F S, Geha R S
Abstract excerpt
Patients with X-linked Ig deficiency with normal or elevated IgM (HIGMX-1) fail to switch from IgM/IgD to other Ig isotypes. Interaction between the B cell antigen CD40 and the CD40 ligand expressed on activated T cells is critical for T cell driven isotype switching. We have reported that T lymp...
Topics
- Antibodies, Monoclonal
- Base Sequence
- CD40 Ligand
- DNA
- Gene Deletion
- Genetic Linkage
- Humans
- Immunoglobulin M
- Immunologic Deficiency Syndromes
- Male
- Membrane Glycoproteins
- Molecular Sequence Data
- Mutation
- X Chromosome