Article
Gsh-4 encodes a LIM-type homeodomain, is expressed in the developing central nervous system and is required for early postnatal survival.
The EMBO journal - 15 Jun 1994
Li H, Witte D P, Branford W W, Aronow B J, Weinstein M, Kaur S, Wert S, Singh G, Schreiner C M, Whitsett J A
Abstract excerpt
We present an initial characterization of the murine Gsh-4 gene which is shown to encode a LIM-type homeodomain. Genes in this category are known to control late developmental cell-type specification events in simpler organisms. Whole mount and serial section in situ hybridizations show transient Gsh-4 expression in ventrolateral regions of the developing neural tube and hindbrain. Mice homozygous for a targeted...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Central Nervous System
- DNA Mutational Analysis
- DNA-Binding Proteins
- Genes, Homeobox
- Genes, Lethal
- Homeodomain Proteins
- In Situ Hybridization