Article
Peripheral microchimerism in long-term cadaveric-kidney allograft recipients.
Lancet (London, England) - 11 Jun 1994
Suberbielle C, Caillat-Zucman S, Legendre C, Bodemer C, Noël L H, Kreis H, Bach J F
Abstract excerpt
Microchimerism after allogeneic organ transplantation may be a mechanism for induction of donor-specific graft acceptance. However, the frequency of chimerism and its relevance in long-term tolerance are uncertain. We studied 15 long-surviving (more than 20 years) cadaveric-kidney transplant recipients for the systemic presence of donor alleles with allele-specific genomic amplification of DRB1 and H-Y loci....
Topics
- Blood Grouping and Crossmatching
- DNA
- Female
- Follow-Up Studies
- Gene Amplification
- Genotype
- Graft Survival
- HLA Antigens
- Humans
- Immune Tolerance
- Kidney Transplantation