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Article

P-glycoprotein binding and modulation of the multidrug-resistant phenotype by estramustine.

Journal of the National Cancer Institute - 4 May 1994

Speicher L A, Barone L R, Chapman A E, Hudes G R, Laing N, Smith C D, Tew K D

Abstract excerpt

BACKGROUND: Previous preclinical studies of combinations of estramustine and vinblastine or paclitaxel (Taxol) have shown that it is possible to achieve a greater than additive cytotoxicity with these antimicrotubule drug combinations. Phase II studies in hormone-refractory prostate cancer have demonstrated clinical antitumor activity of sufficient magnitude to stimulate further laboratory and clinical studies of...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 7908988
DOI: 10.1093/jnci/86.9.688

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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