Article
Isolation of T-cell clones with specificity for arterial antigen from spontaneously hypertensive rats.
Journal of hypertension - 1 Dec 1993
Ofosu-Appiah W, Ruggiero C, Huang L Y
Abstract excerpt
OBJECTIVE: It has been postulated that hypertension in the spontaneously hypertensive rat (SHR) results from autoimmune damage to the SHR vasculature. The objective of this study was to isolate autoreactive T-cells specific for arterial antigens, and to characterize these cells. DESIGN: The prese...
Topics
- Aging
- Animals
- Antibodies, Monoclonal
- Arteries
- Autoantigens
- Autoimmunity
- CD4-Positive T-Lymphocytes
- Clone Cells
- Hypertension
- Interleukin-2
- Lymphocyte Activation
- Lymphokines
- Major Histocompatibility Complex
- Male
- Phenotype
- Rats
- Rats, Inbred SHR
- Rats, Inbred WKY