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Article

Autolysis-defective mutant of Staphylococcus aureus: pathological considerations, genetic mapping, and electron microscopic studies.

Infection and immunity - 1 Apr 1994

Mani N, Baddour L M, Offutt D Q, Vijaranakul U, Nadakavukaren M J, Jayaswal R K

Abstract excerpt

In an earlier report, we had described the isolation and characterization of autolysis-defective mutants of Staphylococcus aureus (N. Mani, P. Tobin, and R.K. Jayaswal, J. Bacteriol. 175:1493-1499, 1993). In the study reported here, an autolysis-defective mutant showed attenuated virulence in a rat model of experimental endocarditis, supporting the role of autolysins in pathogenicity. Transmission electron...

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Identifiers

PMID: 7907580
DOI: 10.1128/iai.62.4.1406-1409.1994
PMCID: PMC186294

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