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Article

Autolysis-defective mutant of Staphylococcus aureus: pathological considerations, genetic mapping, and electron microscopic studies.

Infection and immunity - 1 Apr 1994

Mani N, Baddour L M, Offutt D Q, Vijaranakul U, Nadakavukaren M J, Jayaswal R K

Abstract excerpt

In an earlier report, we had described the isolation and characterization of autolysis-defective mutants of Staphylococcus aureus (N. Mani, P. Tobin, and R.K. Jayaswal, J. Bacteriol. 175:1493-1499, 1993). In the study reported here, an autolysis-defective mutant showed attenuated virulence in a rat model of experimental endocarditis, supporting the role of autolysins in pathogenicity. Transmission electron...

Topics

Animals
Chromosome Mapping
Endocarditis, Bacterial
Male
Microscopy, Electron
Mutation
N-Acetylmuramoyl-L-alanine Amidase
Rats
Rats, Sprague-Dawley
Staphylococcus aureus
Virulence

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Identifiers

PMID: 7907580
DOI: 10.1128/iai.62.4.1406-1409.1994
PMCID: PMC186294

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7907580-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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