Article
Detection of a new apolipoprotein-E mutation in type III hyperlipidemia using deoxyribonucleic acid restriction isotyping.
The Journal of clinical endocrinology and metabolism - 1 Mar 1994
Walden C C, Huff M W, Leiter L A, Connelly P W, Hegele R A
Abstract excerpt
While determining the apolipoprotein-E (apo-E) genotype of 22 patients with type III hyperlipidemia (HLP III) by restriction isotyping, we identified a new mutant form of apo-E by its unusual DNA restriction fragment length polymorphism pattern. DNA sequence analysis of a polymerase chain reactio...
Topics
- Adult
- Aged
- Alleles
- Apolipoproteins E
- Base Sequence
- DNA
- Female
- Genotype
- Humans
- Hyperlipoproteinemia Type III
- Male
- Molecular Sequence Data
- Mutation
- Pedigree
- Phenotype
- Polymerase Chain Reaction
- Polymorphism, Restriction Fragment Length