Linear dose-response relationship and no inverse dose-rate effect observed for low X-ray dose-induced mitotic recombination in Drosophila melanogaster.

Abstract excerpt

Mitotic recombination has emerged lately as a surprisingly common cause of recessive functional gene loss in mammalian cells and has been implicated in tumour suppressor gene loss in human neoplasms. In an assay, primarily monitoring mitotic recombination in Drosophila melanogaster, the ability of low dose acute- and chronic X-ray irradiation to induce clonal expression of recessive mutations of formally...

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