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Article

Ionomycin, Thapsigargin, Ryanodine, and Sperm Induced Ca2+ Release Increase during Meiotic Maturation of Mouse Oocytes

1 Mar 1995

Abstract excerpt

Fertilization of mature mouse oocytes triggered highly repetitive Ca2+ oscillations lasting 2-3 h. However, immature oocytes generated only two or three oscillations, which ceased within 1 h. Development of repetitive Ca2+ transients to sperm occurred late in oocyte maturation and was dependent on cytoplasmic modifications that were independent of cell cycle progression from metaphase I to metaphase II. Immature...

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PMID: 7896808
DOI: 10.1074/jbc.270.12.6671

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