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Article

Genome screening by searching for shared segments: mapping a gene for benign recurrent intrahepatic cholestasis.

Nature genetics - 1 Dec 1994

Houwen R H, Baharloo S, Blankenship K, Raeymaekers P, Juyn J, Sandkuijl L A, Freimer N B

Abstract excerpt

It is now feasible to map disease genes by screening the genome for linkage disequilibrium between the disease and marker alleles. This report presents the first application of this approach for a previously unmapped locus. A gene for benign recurrent intrahepatic cholestasis (BRIC) was mapped to chromosome 18 by searching for chromosome segments shared by only three distantly related patients. The screening...

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Identifiers

PMID: 7894490
DOI: 10.1038/ng1294-380

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Genome screening by searching for shared segments: mapping a gene for benign recurrent intrahepatic cholestasis.PMID 7894490Read ↗

Benign recurrent intrahepatic cholestasis (BRIC): evidence of genetic heterogeneity and delimitation of the BRIC locus to a 7-cM interval between D18S69 and D18S64.Semantic proximity Read ↗

Mapping of a locus for progressive familial intrahepatic cholestasis (Byler disease) to 18q21-q22, the benign recurrent intrahepatic cholestasis region.Semantic proximity Read ↗

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Fine-resolution mapping by haplotype evaluation: the examples of PFIC1 and BRIC.Semantic proximity Read ↗

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