Genome screening by searching for shared segments: mapping a gene for benign recurrent intrahepatic cholestasis.

doi:10.1038/ng1294-380

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Article

Genome screening by searching for shared segments: mapping a gene for benign recurrent intrahepatic cholestasis.

Nature genetics - 1 Dec 1994

Houwen R H, Baharloo S, Blankenship K, Raeymaekers P, Juyn J, Sandkuijl L A, Freimer N B

Abstract excerpt

It is now feasible to map disease genes by screening the genome for linkage disequilibrium between the disease and marker alleles. This report presents the first application of this approach for a previously unmapped locus. A gene for benign recurrent intrahepatic cholestasis (BRIC) was mapped to...

Topics

Cholestasis, Intrahepatic
Chromosome Mapping
Chromosomes, Human, Pair 18
Female
Genotype
Haplotypes
Humans
Male
Pedigree
Probability
Recurrence

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