Article
Benign recurrent intrahepatic cholestasis (BRIC): evidence of genetic heterogeneity and delimitation of the BRIC locus to a 7-cM interval between D18S69 and D18S64.
Human genetics - 1 Sept 1997
Sinke R J, Carlton V E, Juijn J A, Delhaas T, Bull L, van Berge Henegouwen G P, van Hattum J, Keller K M, Sinaasappel M, Bijleveld C M, Knol I E, Ploos van Amstel H K, Pearson P L, Berger R, Freimer N B, Houwen R H
Abstract excerpt
Benign recurrent intrahepatic cholestasis (BRIC) is an autosomal recessive liver disease characterized by multiple episodes of cholestasis without progression to chronic liver disease. The gene was previously assigned to chromosome 18q21, using a shared segment analysis in three families from the...
Topics
- Cholestasis, Intrahepatic
- Chromosome Mapping
- Chromosomes, Human, Pair 18
- Female
- Genetic Heterogeneity
- Genotype
- Humans
- Male
- Microsatellite Repeats
- Pedigree
- Recurrence