Fine-resolution mapping by haplotype evaluation: the examples of PFIC1 and BRIC.

doi:10.1007/pl00008714

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Article

Fine-resolution mapping by haplotype evaluation: the examples of PFIC1 and BRIC.

Human genetics - 1 Mar 1999

Bull L N, Juijn J A, Liao M, van Eijk M J, Sinke R J, Stricker N L, DeYoung J A, Carlton V E, Baharloo S, Klomp L W, Abukawa D, Barton D E, Bass N M, Bourke B, Drumm B, Jankowska I, Lovisetto P, McQuaid S, Pawlowska J, Tazawa Y, Villa E, Tygstrup N, Berger R, Knisely A S, Freimer N B

Abstract excerpt

Loci for two inherited liver diseases, benign recurrent intrahepatic cholestasis (BRIC) and progressive familial intrahepatic cholestasis type 1 (PFIC1), have previously been mapped to 18q21 by a search for shared haplotypes in patients in two isolated populations. This paper describes the use of further haplotype evaluation with a larger sample of patients for both disorders, drawn from several different...

Topics

Cholestasis, Intrahepatic
Chromosome Mapping
Family Health
Genetic Markers
Genotype
Haplotypes
Humans

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 10323248
DOI: 10.1007/pl00008714

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