Article
Functional role of the cis-acting elements in human monocyte chemotactic protein-1 gene in the regulation of its expression by phorbol ester in human glioblastoma cells.
Molecular and cellular biochemistry - 21 Dec 1994
Li Y S, Kolattukudy P E
Abstract excerpt
The monocyte chemotactic protein-1 (MCP-1) is a 76 amino acid protein that specifically attracts monocytes. The expression of MCP-1 gene can be induced by lipopolysaccharides (LPS), phorbol esters (TPA) and several cytokines. However, how they regulate MCP-1 gene expression is not known. We teste...
Topics
- Base Sequence
- Chemokine CCL2
- Chemotactic Factors
- Chloramphenicol O-Acetyltransferase
- DNA
- Gene Expression Regulation
- Genes, Reporter
- Glioblastoma
- Humans
- Lipopolysaccharides
- Molecular Sequence Data
- Mutation
- Promoter Regions, Genetic
- Regulatory Sequences, Nucleic Acid
- Tetradecanoylphorbol Acetate
- Transfection
- Tumor Cells, Cultured
- Tumor Necrosis Factor-alpha