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Article

Structure of the periplasmic stress response protein CpxP.

Journal of bacteriology - 1 May 2011

Thede Gina L, Arthur David C, Edwards Ross A, Buelow Daelynn R, Wong Julia L, Raivio Tracy L, Glover J N Mark

Abstract excerpt

CpxP is a novel bacterial periplasmic protein with no homologues of known function. In gram-negative enteric bacteria, CpxP is thought to interact with the two-component sensor kinase, CpxA, to inhibit induction of the Cpx envelope stress response in the absence of protein misfolding. CpxP has also been shown to facilitate DegP-mediated proteolysis of misfolded proteins. Six mutations that negate the ability of...

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Identifiers

PMID: 21317318
DOI: 10.1128/JB.01296-10
PMCID: PMC3133086

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Structure of the periplasmic stress response protein CpxP.PMID 21317318Read ↗

[Mutation of the envelope stress-responsive protein CpxA capable of regulating the antimicrobial resistance and virulence of bacteria].Semantic proximity Read ↗

The Cpx two-component signal transduction pathway of Escherichia coli regulates transcription of the gene specifying the stress-inducible periplasmic protease, DegP.Semantic proximity Read ↗

Transduction of envelope stress in Escherichia coli by the Cpx two-component system.Semantic proximity Read ↗

DegP is involved in Cpx-mediated posttranscriptional regulation of the type III secretion apparatus in enteropathogenic Escherichia coli.Semantic proximity Read ↗

Fine-Tuning of the Cpx Envelope Stress Response Is Required for Cell Wall Homeostasis in Escherichia coli.Semantic proximity Read ↗

Regulation of Escherichia coli cell envelope proteins involved in protein folding and degradation by the Cpx two-component system.Semantic proximity Read ↗

Mutational activation of the Cpx signal transduction pathway of Escherichia coli suppresses the toxicity conferred by certain envelope-associated stresses.Semantic proximity Read ↗

The inner cavity of Escherichia coli DegP protein is not essential for molecular chaperone and proteolytic activity.Semantic proximity Read ↗

The Cpx envelope stress response affects expression of the type IV bundle-forming pili of enteropathogenic Escherichia coli.Semantic proximity Read ↗

Steric clashes with bound OMP peptides activate the DegS stress-response protease.Semantic proximity Read ↗

Cpx two-component signal transduction in Escherichia coli: excessive CpxR-P levels underlie CpxA* phenotypes.Semantic proximity Read ↗

Phylogenetic analysis predicts structural divergence for proteobacterial ClpC proteins.Semantic proximity Read ↗

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