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Article

Evidence of a steroidogenic enzyme gene dose effect on adrenal gene expression in hereditary rabbit congenital adrenal hyperplasia.

Pediatric research - 1 Nov 1994

Iwamoto K, Yang X, Rogerson F M, Mason J I, Artwohl J, Bolin K, Klimah P, Swart P, Pang S

Abstract excerpt

We previously reported the gene deletion encoding cytochrome P-450 cholesterol side-chain cleavage enzyme (P-450SCC, resulting in complete elimination of the adrenal gene expression and causing congenital adrenal hyperplasia in the rabbit. Using the rabbit congenital adrenal hyperplasia model, we investigated the wild type (wt) P-450SCC gene dose effect on gene expression in three P-450SCC genotype animals...

Topics

Adrenal Glands
Adrenal Hyperplasia, Congenital
Aging
Animals
Animals, Newborn
Cholesterol Side-Chain Cleavage Enzyme
Gene Dosage
Gene Expression
Genotype
Heterozygote
Homozygote

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Pedigree

Phenotype

RNA, Messenger

Rabbits

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Identifiers

PMID: 7877888
DOI: 10.1203/00006450-199411000-00023

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7877888-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Evidence of a steroidogenic enzyme gene dose effect on adrenal gene expression in hereditary rabbit congenital adrenal hyperplasia.PMID 7877888Read ↗

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