Article
Genotype at the P450scc locus determines differences in the amount of P450scc protein and maximal testosterone production in mouse Leydig cells.
Molecular endocrinology (Baltimore, Md.) - 1 Oct 1990
Nolan C J, Payne A H
Abstract excerpt
A genetic difference in maximal testosterone production in Leydig cells relates to differences in the genotype at the P450scc locus. The genetic relationship between the P450scc gene, the amount of Leydig cell P450scc protein, and maximal testosterone production was determined in the F2 generatio...
Topics
- 3-Hydroxysteroid Dehydrogenases
- Alleles
- Animals
- Cholesterol Side-Chain Cleavage Enzyme
- Chromosome Mapping
- Cyclic AMP
- Female
- Genotype
- Homozygote
- Leydig Cells
- Male
- Mice
- Mice, Inbred C3H
- Mice, Inbred DBA
- Polymorphism, Restriction Fragment Length
- Steroid 17-alpha-Hydroxylase
- Testosterone