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Article

The association of factor V Leiden with myocardial infarction is replicated in 1880 patients with premature disease.

Journal of thrombosis and haemostasis : JTH - 1 Oct 2010

Mannucci P M, Asselta R, Duga S, Guella I, Spreafico M, Lotta L, Merlini P A, Peyvandi F, Kathiresan S, Ardissino D

Abstract excerpt

UNLABELLED: AIMS: Gain-of-function variants of genes encoding coagulation factor V (F5 G1691A) and prothrombin (F2 G20210A) cause hypercoagulability and are established risk factors for venous thrombosis. A meta-analysis of 66,155 cases and 91,307 controls found that either polymorphism is associated with a moderately increased risk of coronary artery disease (CAD). Because genetic factors play a particularly...

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Source

Identifiers

PMID: 20626623
DOI: 10.1111/j.1538-7836.2010.03982.x

Genes

CAD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The association of factor V Leiden with myocardial infarction is replicated in 1880 patients with premature disease.PMID 20626623Read ↗

Prothrombotic gene variants as risk factors of acute myocardial infarction in young women.Semantic proximity Read ↗

Analysis of polymorphisms Leiden Factor V G1691A and prothrombin G20210A as risk factors for acute myocardial infarction.Semantic proximity Read ↗

Genome-wide analyses of early-onset acute myocardial infarction identify 29 novel loci by whole genome sequencingSemantic proximity Read ↗

Increased prevalence of the G20210A prothrombin gene variant in acute coronary syndromes without metabolic or acquired risk factors or with limited extent of disease.Semantic proximity Read ↗

Multiple thrombophilia mutations as a possible cause of premature myocardial infarction.Semantic proximity Read ↗

Genetic variation in coagulation and fibrinolytic proteins and their relation with acute myocardial infarction: a systematic review.Semantic proximity Read ↗

Prevalence of factor V gene mutation amongst myocardial infarction patients and healthy controls is higher in Sweden than in other countries.Semantic proximity Read ↗

No evidence of association between prothrombotic gene polymorphisms and the development of acute myocardial infarction at a young age.Semantic proximity Read ↗

Genetic factors of the hemostatic system in young patients with myocardial infarction.Semantic proximity Read ↗

Polymorphisms in coagulation factors and the risk of recurrent cardiovascular events in men after a first myocardial infarction.Semantic proximity Read ↗

Thrombophilia in young patients with acute myocardial infarction.Semantic proximity Read ↗

Prothrombin 20210GA and factor V Leiden mutations in patients less than 55 years old with myocardial infarction.Semantic proximity Read ↗

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