Retention and retrieval: both mechanisms cooperate to maintain calreticulin in the endoplasmic reticulum.

doi:10.1242/jcs.107.10.2705

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Article

Retention and retrieval: both mechanisms cooperate to maintain calreticulin in the endoplasmic reticulum.

Journal of cell science - 1 Oct 1994

Sönnichsen B, Füllekrug J, Nguyen Van P, Diekmann W, Robinson D G, Mieskes G

Abstract excerpt

Many soluble resident proteins of the endoplasmic reticulum share a COOH-terminal Lys-Asp-Glu-Leu (KDEL) sequence. Current opinion favours a model in which these proteins can escape from the endoplasmic reticulum (ER) by bulk flow and are recognized and sorted in the Golgi apparatus by binding to a specific KDEL-receptor, which returns them to the ER. Through biochemical, morphological and mutational analysis we...

Topics

Amino Acid Sequence
Animals
Base Sequence
Biological Transport
CHO Cells
Calcium-Binding Proteins
Calreticulin
Cell Line
Cricetinae
DNA, Complementary
Endoplasmic Reticulum

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Liposomes

Molecular Sequence Data

Molecular Weight

Mutation

Ribonucleoproteins

Signal Transduction

Source

Open in PubMed

Identifiers

PMID: 7876339
DOI: 10.1242/jcs.107.10.2705

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7876339-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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