Article
1H NMR analysis of fibril-forming peptide fragments of transthyretin.
International journal of peptide and protein research - 1 Oct 1994
Jarvis J A, Kirkpatrick A, Craik D J
Abstract excerpt
Peptide fragments of the protein transthyretin, previously shown to form cross beta-sheet amyloid-like fibrils in vitro, were investigated using 1H 1D and 2D NMR techniques. TTR 10-20, TTR 105-115 as well as a substituted analogue, (TTR 105-115Met111) all formed amyloid-like fibrils readily in 20-30% acetonitrile/water at room temperature. It was found that the presence of fibrils in the peptide solutions did not...
Topics
- Amino Acid Sequence
- Deuterium
- Magnetic Resonance Spectroscopy
- Molecular Sequence Data
- Mutation
- Peptide Fragments
- Prealbumin
- Protein Folding
- Protein Structure, Secondary
- Temperature