Article
Superoxide dismutase protects Escherichia coli against killing by human serum.
Archives of biochemistry and biophysics - 20 Feb 1995
McManus D C, Josephy P D
Abstract excerpt
To assess the role of superoxide dismutase in protecting Escherichia coli from killing by human serum and neutrophils, we constructed isogenic, smooth-lipopolysaccharide K-12 strains, either sod wild-type, delta sodA, or delta sodA delta sodB. The delta sodA delta sodB strain was killed by serum much more readily than either the wild-type or delta sodA strain. After allowing for this serum sensitivity difference,...
Topics
- Complement System Proteins
- Cytotoxicity, Immunologic
- Escherichia coli
- Humans
- Hydrogen Peroxide
- Lipopolysaccharides
- Mutation
- Neutrophils
- Respiratory Burst
- Superoxide Dismutase