Article
Superoxide dismutase C is required for intracellular survival and virulence of Burkholderia pseudomallei
10 Jun 2011
Abstract excerpt
Burkholderia pseudomallei is an intracellular pathogen and the causative agent of melioidosis, a life-threatening disease of humans. Within host cells, superoxide is an important mediator of pathogen killing. In this study, we have identified the B. pseudomallei K96243 sodC gene, shown that it has superoxide dismutase activity, and constructed an allelic deletion mutant of this gene. Compared with the wild-type,...
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