Article
Co-mutation of HPV16 E6 and E7 genes in Thai squamous cervical carcinomas.
Anticancer research - 1 Jan 2000
Vaeteewoottacharn Kulthida, Jearanaikoon Patcharee, Ponglikitmongkol Mathurose
Abstract excerpt
Infection with high-risk HPV16 is well associated with invasive cervical carcinomas. Variations in the E6 gene of HPV16 are shown to correlate with both the geographical areas and the oncogenicity. Here, we have characterized HPV16 DNA variants in the E6 and E7 coding regions of 31 Thai cervical squamous cell carcinomas. Five groups of E6 variants were identified. A mutation from T to G at nucleotide 178, leading...
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