Article
Mouse silver mutation is caused by a single base insertion in the putative cytoplasmic domain of Pmel 17.
Nucleic acids research - 11 Jan 1995
Kwon B S, Halaban R, Ponnazhagan S, Kim K, Chintamaneni C, Bennett D, Pickard R T
Abstract excerpt
This laboratory has established in previous studies that Pmel 17, a gene expressed specifically in melanocytes, maps near the silver coat color locus (si/si) on mouse chromosome 10. In the current study, we have focused on determining whether or not the si allele carries a mutation in Pmel 17. Pm...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Cells, Cultured
- DNA Primers
- DNA, Complementary
- Immunochemistry
- Melanocytes
- Membrane Glycoproteins
- Mice
- Molecular Sequence Data
- Mutation
- Polymorphism, Restriction Fragment Length
- Proteins
- gp100 Melanoma Antigen