Article
Effects of the developmental colour mutations silver and recessive spotting on proliferation of diploid and immortal mouse melanocytes in culture.
Development (Cambridge, England) - 1 Mar 1992
Spanakis E, Lamina P, Bennett D C
Abstract excerpt
The developmental mouse coat-colour mutations silver (si, chromosome 10) and recessive spotting (rs, chromosome 5, mapping very close to the dominant white spotting or W/c-kit locus), appear to reduce the numbers of functional melanocytes in the skin. They were studied at the cellular level by melanocyte culture. Cellular morphology, differentiation and survival appeared normal. However, both mutations were found...
Topics
- Animals
- Cell Division
- Cells, Cultured
- Genes
- Genes, Recessive
- Keratinocytes
- Melanocytes
- Mice
- Mice, Inbred Strains
- Mutation
- Phenotype
- Pigmentation