Article
Approach to the involvement of influenza B neuraminidase in the cleavage of HA by host cell protease using low pH-induced cell fusion reaction.
Microbiology and immunology - 1 Jan 1994
Yamamoto-Goshima F, Maeno K
Abstract excerpt
ts7, a temperature-sensitive mutant defective in neuraminidase (NA) of influenza B/Kanagawa/73, lacks NA enzymatic activity at the nonpermissive temperature (37.5 C). When MDCK cells were infected with the mutant at the permissive temperature (32 C) and exposed to pH 5.2 medium, extensive cell fu...
Topics
- Animals
- Cell Fusion
- Cell Line
- Dogs
- Endopeptidases
- Hemagglutinins, Viral
- Hydrogen-Ion Concentration
- Influenza B virus
- Kidney
- Mutation
- Neuraminidase
- Temperature