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Expression of the mutant allele of IT-15 (the HD gene) in striatum and cortex of Huntington's disease patients.

Human molecular genetics - 1 Jan 1995

Stine O C, Li S H, Pleasant N, Wagster M V, Hedreen J C, Ross C A

Abstract excerpt

Huntington's disease (HD) is an inherited neurodegenerative disorder expressed when a trinucleotide repeat in the gene IT-15 is expanded. The mechanism by which the expanded repeat causes the expression of the disease is unknown. Possible mechanisms include alterations in the amount of the mRNA, potentially resulting from changes in gene transcription or abnormal mRNA stability. In order to determine whether the...

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PMID: 7711729
DOI: 10.1093/hmg/4.1.15

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Expression of the mutant allele of IT-15 (the HD gene) in striatum and cortex of Huntington's disease patients.PMID 7711729Read ↗

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Increased Steady-State Mutant Huntingtin mRNA in Huntington's Disease BrainSemantic proximity Read ↗

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Mutant huntingtin's effects on striatal gene expression in mice recapitulate changes observed in human Huntington's disease brain and do not differ with mutant huntingtin length or wild-type huntingtin dosage.Semantic proximity Read ↗

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