Article
Expression of the mutant allele of IT-15 (the HD gene) in striatum and cortex of Huntington's disease patients.
Human molecular genetics - 1 Jan 1995
Stine O C, Li S H, Pleasant N, Wagster M V, Hedreen J C, Ross C A
Abstract excerpt
Huntington's disease (HD) is an inherited neurodegenerative disorder expressed when a trinucleotide repeat in the gene IT-15 is expanded. The mechanism by which the expanded repeat causes the expression of the disease is unknown. Possible mechanisms include alterations in the amount of the mRNA,...
Topics
- Alleles
- Base Sequence
- Cerebral Cortex
- Corpus Striatum
- DNA Primers
- Humans
- Huntingtin Protein
- Huntington Disease
- Molecular Sequence Data
- Mutation
- Nerve Tissue Proteins
- Nuclear Proteins