Article
Neuropathological phenotype and 'prion protein' genotype correlation in sporadic Creutzfeldt-Jakob disease.
Neuroscience letters - 26 Sept 1994
de Silva R, Ironside J W, McCardle L, Esmonde T, Bell J, Will R, Windl O, Dempster M, Estibeiro P, Lathe R
Abstract excerpt
A systematic study of 'prion protein' genotype in cases of sporadic Creutzfeldt-Jakob disease showing amyloid plaques staining with anti-prion protein antibody has been performed. This revealed a relative excess of cases with valine at position 129 of the gene's open reading frame. The observatio...
Topics
- Aged
- Aged, 80 and over
- Amyloid
- Amyloidosis
- Creutzfeldt-Jakob Syndrome
- DNA
- Genotype
- Humans
- Methionine
- Middle Aged
- Open Reading Frames
- Phenotype
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Prions
- Valine