Article
Allelic variations in apolipoprotein E and prion protein genotype related to plaque formation and age of onset in sporadic Creutzfeldt-Jakob disease.
Neuroscience letters - 3 Mar 1995
Pickering-Brown S M, Mann D M, Owen F, Ironside J W, de Silva R, Roberts D A, Balderson D J, Cooper P N
Abstract excerpt
Prion gene sequence is thought to affect the phenotypic expression of prion disease and the E2 variant of apolipoprotein E (Apo E) can be neuroprotective in dementia. We determined codon 129 of the prion gene and the Apo E variants in Creutzfeldt-Jakob disease (CJD) using PCR and restriction digest. We found a significant correlation between valine at codon 129 of the prion protein gene and the presence of plaque...
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