Article
Allelic variations in apolipoprotein E and prion protein genotype related to plaque formation and age of onset in sporadic Creutzfeldt-Jakob disease.
Neuroscience letters - 3 Mar 1995
Pickering-Brown S M, Mann D M, Owen F, Ironside J W, de Silva R, Roberts D A, Balderson D J, Cooper P N
Abstract excerpt
Prion gene sequence is thought to affect the phenotypic expression of prion disease and the E2 variant of apolipoprotein E (Apo E) can be neuroprotective in dementia. We determined codon 129 of the prion gene and the Apo E variants in Creutzfeldt-Jakob disease (CJD) using PCR and restriction dige...
Topics
- Age of Onset
- Aged
- Alleles
- Apolipoproteins E
- Creutzfeldt-Jakob Syndrome
- Female
- Genotype
- Humans
- Male
- Middle Aged
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Prions