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Article

[p53: an important or most overvalued tumor gene?].

Laryngo- rhino- otologie - 1 Dec 1994

Schlegel U

Abstract excerpt

Mutations in the tumour-suppressor gene p53 are the most frequent molecular alterations detected in human tumours. p53 protein, which has been called "guardian of the genome", seems to play a key role in cellular DNA repair. Loss of p53 protein function by genetic mutation thereby makes the cell vulnerable to DNA damage, and disposes it to malignant transformation. In different human tumour types the prognostic...

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Identifiers

PMID: 7840829
DOI: 10.1055/s-2007-997215

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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