[p53: an important or most overvalued tumor gene?].

doi:10.1055/s-2007-997215

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Article

[p53: an important or most overvalued tumor gene?].

Laryngo- rhino- otologie - 1 Dec 1994

Schlegel U

Abstract excerpt

Mutations in the tumour-suppressor gene p53 are the most frequent molecular alterations detected in human tumours. p53 protein, which has been called "guardian of the genome", seems to play a key role in cellular DNA repair. Loss of p53 protein function by genetic mutation thereby makes the cell...

Topics

Astrocytoma
Brain Neoplasms
Breast Neoplasms
Cell Transformation, Neoplastic
Chromosome Deletion
Chromosomes, Human, Pair 17
Colonic Neoplasms
DNA Damage
DNA Repair
Glioblastoma
Humans
Mutation
Neoplasm Recurrence, Local
Prognosis
Tumor Suppressor Protein p53

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